Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice.

@article{Gussow2006TissuespecificSO,
  title={Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice.},
  author={Anne M. Gussow and Nicole V. Giordani and Robert K. Tran and Yumi Imai and Dacia L. Kwiatkowski and Glenn F Rall and Todd Margolis and David C. Bloom},
  journal={Journal of virology},
  year={2006},
  volume={80 19},
  pages={9414-23}
}
To study the regulation of herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) expression and processing in the absence of other cis and trans viral functions, a transgenic mouse containing the region encompassing the LAT promoter (LAP1) and the LAT 5' exon through the 2.0-kb intron was created. LAT expression was detectable by reverse transcriptase PCR (RT-PCR) in a number of tissues, including the dorsal root ganglia (DRG), trigeminal ganglia (TG), brain, skin, liver, and… CONTINUE READING

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