Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif.

@article{Faccio2000TissuespecificSO,
  title={Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif.},
  author={Lucian Faccio and Cristiana Fusco and Alessandra Viel and Antonis S. Zervos},
  journal={Genomics},
  year={2000},
  volume={68 3},
  pages={343-7}
}
Omi is a human serine protease whose catalytic domain is homologous to a bacterial heat shock endoprotease (HtrA), a protein indispensable to the survival of bacteria at elevated temperatures. Omi is expressed ubiquitously, and its protein product is predominantly localized in the endoplasmic reticulum of mammalian cells. Here we present the genomic structure of Omi, consisting of eight exons located on human chromosome 2p12-p13. Furthermore, we describe an alternatively splice form of Omi (D… CONTINUE READING