Tissue specific response to DNA damage: C. elegans as role model.

@article{Lans2015TissueSR,
  title={Tissue specific response to DNA damage: C. elegans as role model.},
  author={H. Lans and W. Vermeulen},
  journal={DNA repair},
  year={2015},
  volume={32},
  pages={
          141-148
        }
}
The various symptoms associated with hereditary defects in the DNA damage response (DDR), which range from developmental and neurological abnormalities and immunodeficiency to tissue-specific cancers and accelerated aging, suggest that DNA damage affects tissues differently. Mechanistic DDR studies are, however, mostly performed in vitro, in unicellular model systems or cultured cells, precluding a clear and comprehensive view of the DNA damage response of multicellular organisms. Studies… Expand
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