Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.

@article{Murtazina2007TissuespecificRO,
  title={Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.},
  author={Rakhilya Murtazina and Olga N Kovbasnjuk and Nicholas C. Zachos and Xuhang Li and Yueping Chen and Ann Hubbard and Boris M Hogema and Deborah Ann Steplock and Ursula Seidler and Kazi Hoque and Chung Ming Tse and Hugo R. de Jonge and Edward J. Weinman and Mark Donowitz},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 34},
  pages={25141-51}
}
The multi-PDZ domain containing protein Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) binds to Na(+)/H(+) exchanger 3 (NHE3) and is associated with the brush border (BB) membrane of murine kidney and small intestine. Although studies in BB isolated from kidney cortex of wild type and NHERF1(-/-) mice have shown that NHERF1 is necessary for cAMP inhibition of NHE3 activity, a role of NHERF1 in NHE3 regulation in small intestine and in intact kidney has not been established. Here a method… CONTINUE READING

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