Tissue-specific regulation of fatty acid synthesis by thyroid hormone.

  title={Tissue-specific regulation of fatty acid synthesis by thyroid hormone.},
  author={Beate Blennemann and Yangha Kim Moon and Hedley Christopher Freake},
  volume={130 2},
It is generally agreed that thyroid hormone stimulates the hepatic synthesis of long chain fatty acids in the rat. However, there are conflicting data about its effects in white adipose tissue, while in brown adipose tissue, lipogenic rates are highest in hypothyroid animals. We have systematically examined the effect of thyroid state on lipogenesis in different rat tissues. Fatty acid synthesis was assessed in vivo, using the incorporation of tritiated water. Hepatic lipogenesis was induced 16… CONTINUE READING