Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus.

@article{Chikuma2000TissuespecificRO,
  title={Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus.},
  author={Mariko Chikuma and Seiji Masuda and Tetsuro Kobayashi and Motoshi Nagao and Ryouhei Sasaki},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={279 6},
  pages={E1242-8}
}
Erythropoietin (Epo) produced by the kidney regulates erythropoiesis. Recent evidence suggests that Epo in the cerebrum prevents neuron death and Epo in the uterus induces estrogen (E(2))-dependent uterine angiogenesis. To elucidate how Epo expression is regulated in these tissues, ovariectomized mice were given E(2) and/or exposed to hypoxia, and the temporal patterns of Epo mRNA levels were examined. Epo mRNA levels in the kidney and cerebrum were elevated markedly within 4 h after exposure… CONTINUE READING

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