Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes

@article{Serizay2020TissuespecificPR,
  title={Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes},
  author={Jacques Serizay and Yan Dong and J{\"u}rgen J{\"a}nes and Michael A. Chesney and Chiara Cerrato and Julie Ahringer},
  journal={bioRxiv},
  year={2020}
}
Despite increasingly detailed knowledge of gene expression patterns, the regulatory architectures that drive them are not well understood. To address this, we compared transcriptional and regulatory element activities across five adult tissues of C. elegans, covering ∼90% of cells, and defined regulatory grammars associated with ubiquitous, germline and somatic tissue-specific gene expression patterns. We find architectural features that distinguish two major promoter types. Germline-specific… 
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