Tissue-specific nuclear architecture and gene expession regulated by SATB1

@article{Cai2003TissuespecificNA,
  title={Tissue-specific nuclear architecture and gene expession regulated by SATB1},
  author={Shutao Cai and Hye-jung Han and Terumi Kohwi-Shigematsu},
  journal={Nature Genetics},
  year={2003},
  volume={34},
  pages={42-51}
}
Eukaryotic chromosomes are packaged in nuclei by many orders of folding. Little is known about how higher-order chromatin packaging might affect gene expression. SATB1 is a cell-type specific nuclear protein that recruits chromatin-remodeling factors and regulates numerous genes during thymocyte differentiation. Here we show that in thymocyte nuclei, SATB1 has a cage-like 'network' distribution circumscribing heterochromatin and selectively tethers specialized DNA sequences onto its network… 
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