Tissue-specific knockout defines peroxisome proliferator-activated receptor gamma function in muscle and liver.

@article{Wolf2004TissuespecificKD,
  title={Tissue-specific knockout defines peroxisome proliferator-activated receptor gamma function in muscle and liver.},
  author={George H. Wolf},
  journal={Nutrition reviews},
  year={2004},
  volume={62 6 Pt 1},
  pages={
          253-5
        }
}
Although the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed mostly in adipose tissue, it also occurs in skeletal muscle and liver. Mice lacking a functional PPARgamma gene, specifically in muscle, showed increased adiposity with reduced caloric intake, resulting from shunting of lipid to the liver. This result suggested a function for muscle PPARgamma in the up-regulation of muscle lipid metabolism. A study in lipoatrophic mice--that were also… CONTINUE READING