Tissue-specific impairment of insulin signaling in vasculature and skeletal muscle of fructose-fed rats.

@article{Hyakukoku2003TissuespecificIO,
  title={Tissue-specific impairment of insulin signaling in vasculature and skeletal muscle of fructose-fed rats.},
  author={M. Hyakukoku and K. Higashiura and N. Ura and H. Murakami and Koichi Yamaguchi and L. Wang and M. Furuhashi and N. Togashi and K. Shimamoto},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2003},
  volume={26 2},
  pages={
          169-76
        }
}
  • M. Hyakukoku, K. Higashiura, +6 authors K. Shimamoto
  • Published 2003
  • Chemistry, Medicine
  • Hypertension research : official journal of the Japanese Society of Hypertension
  • The relation between insulin resistance/hyperinsulinemia and cardiovascular diseases has attracted much attention. Insulin affects not only glucose metabolism, but also protein synthesis and cell growth. Insulin stimulates both the phosphatidylinositol 3-kinase (PI3-K) and mitogen-activated protein kinase (MAPK) pathways, but the relationship between cardiovascular disease and selective insulin signal pathways is unclear. We investigated the tissue specificity and intracellular signal… CONTINUE READING
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