Tissue-specific function of farnesoid X receptor in liver and intestine.

  title={Tissue-specific function of farnesoid X receptor in liver and intestine.},
  author={Yan Zhu and Fei Li and Grace L. Guo},
  journal={Pharmacological research},
  volume={63 4},
Nuclear receptors (NRs) are ligand-activated transcriptional factors that are involved in various physiological, developmental, and toxicological processes. Farnesoid X receptor (FXR) is a NR that belongs to the NR superfamily. The endogenous ligands of FXR are bile acids. FXR is essential in regulating a network of genes involved in maintaining bile acid and lipid homeostasis. It is clear that FXR is critical for liver and intestinal function. In mice FXR deficiency leads to the development of… CONTINUE READING
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