Tissue-specific forms of type IX collagen-proteoglycan arise from the use of two widely separated promoters.

@article{Nishimura1989TissuespecificFO,
  title={Tissue-specific forms of type IX collagen-proteoglycan arise from the use of two widely separated promoters.},
  author={Ichiro Nishimura and Yasuteru Muragaki and Bjorn Reino Olsen},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 33},
  pages={20033-41}
}
We demonstrate that the gene encoding an extracellular matrix component contains two widely separated promoters controlling the generation of different transcripts in a tissue-specific fashion. Two transcription start sites, about 20 kilobase pairs apart, in the alpha 1(IX) collagen gene are utilized to generate different forms of a collagen-proteoglycan (collagen IX) in chicken cartilage and cornea. Transcripts from the upstream site encode a large (266 amino acid residues) globular domain at… CONTINUE READING

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