Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.

@article{Wei1997TissuespecificEO,
  title={Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.},
  author={Chungwen Wei and Rupert Allan Willis and Brian R. Tilton and Richard John Looney and Edith M. Lord and Richard K. Barth and John G. Frelinger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 12},
  pages={
          6369-74
        }
}
Human prostate-specific antigen (PSA) has been widely used as a serum marker for cancer of the prostate. The cell type-specific expression of PSA also makes it a potential tumor antigen for prostate cancer immunotherapy. Study of the immunological aspects of PSA within either normal or malignant prostate tissue has been hampered by the lack of a mouse model, because no PSA counterpart has been identified in mice. Using a 14-kb genomic DNA region that encompasses the entire human PSA gene and… CONTINUE READING

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