Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo

  title={Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo},
  author={Richard Mollard and St{\'e}phane Viville and Simon J. Ward and Didier D{\'e}cimo and Pierre Chambon and Pascal Doll{\'e}},
  journal={Mechanisms of Development},
The three murine retinoic acid receptor (RAR) genes each contain two distinct promoters which give rise to protein isoforms differing in their N-terminal regions. This study used in situ hybridization to describe the expression patterns of RARalpha1, RARalpha2, RARbeta1/3, RARbeta2/4, RARgamma1 and RARgamma2 isoform transcripts during mouse embryogenesis. RARalpha1 transcripts are widely distributed, with the exception of the central nervous system. Highest expression is found in developing… CONTINUE READING


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