Tissue-specific expression of p53 and ras genes in response to the environmental genotoxicant benzo(α)pyrene in marine mussels.

@article{Di2011TissuespecificEO,
  title={Tissue-specific expression of p53 and ras genes in response to the environmental genotoxicant benzo(α)pyrene in marine mussels.},
  author={Yanan Di and Declan C. Schroeder and Andrea Highfield and James W Readman and Awadhesh N Jha},
  journal={Environmental science & technology},
  year={2011},
  volume={45 20},
  pages={
          8974-81
        }
}
Marine mussels can develop hemeic and gonadal neoplasia in the natural environment. Associated with these diseases are the tumor suppressor (TS) p53 and the proto-oncogene ras coded proteins, both of which are highly conserved among molluscs and vertebrates. We report, for the first time, tissue-specific expression analysis of p53 and ras genes in Mytilus edulis by means of quantitative RT-PCR. A tissue-specific response was observed after 6 and 12 days exposure to a sublethal concentration of… CONTINUE READING

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