Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.

@article{Miller2002TissuespecificEO,
  title={Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.},
  author={Hugh R. P. Miller and Alan David Pemberton},
  journal={Immunology},
  year={2002},
  volume={105 4},
  pages={
          375-90
        }
}
Serine proteinases with trypsin-like (tryptase) and chymotrypsin-like (chymase) properties are major constituents of mast cell granules. Several tetrameric tryptases with differing specificities have been characterized in humans, but only a single chymase. In other species there are larger families of chymases with distinct and narrow proteolytic specificities. Expression of chymases and tryptases varies between tissues. Human pulmonary and gastrointestinal mast cells express chymase at lower… CONTINUE READING
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