Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality.

@article{Elefant1999TissuespecificEO,
  title={Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality.},
  author={Felice Elefant and Karen B. Palter},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 7},
  pages={
          2101-17
        }
}
The Drosophila melanogaster HSC3 and HSC4 genes encode Hsc70 proteins homologous to the mammalian endoplasmic reticulum (ER) protein BiP and the cytoplasmic clathrin uncoating ATPase, respectively. These proteins possess ATP binding/hydrolysis activities that mediate their ability to aid in protein folding by coordinating the sequential binding and release of misfolded proteins. To investigate the roles of HSC3 (Hsc3p) and HSC4 (Hsc4p) proteins during development, GAL4-targeted gene expression… CONTINUE READING

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