Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram.

@article{Zars2000TissuespecificEO,
  title={Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram.},
  author={Troy Zars and Reinhard Wolf and Richard 1. Davis and Martin Heisenberg},
  journal={Learning & memory},
  year={2000},
  volume={7 1},
  pages={18-31}
}
Most attempts to localize physical correlates of memory in the central nervous system (CNS) rely on ablation techniques. This approach has the limitation of defining just one of an unknown number of structures necessary for memory formation. We have used the Drosophila rutabaga type I Ca(2+)/CaM-dependent adenylyl cyclase (AC) gene to determine in which CNS region AC expression is sufficient for memory formation. Using pan-neural and restricted CNS expression with the GAL4 binary transcription… CONTINUE READING
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