Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity

  title={Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity},
  author={Joyce Wei and P’ng Loke and Xingxing Zang and James P Allison},
  booktitle={The Journal of experimental medicine},
B7x, an inhibitory member of the B7/CD28 superfamily, is highly expressed in a broad range of nonhematopoietic organs, suggesting a role in maintaining peripheral tolerance. As endogenous B7x protein is expressed in pancreatic islets, we investigated whether the molecule inhibits diabetogenic responses. Transfer of disease-inducing BDC2.5 T cells into B7x-deficient mice resulted in a more aggressive form of diabetes than in wild-type animals. This exacerbation of disease correlated with higher… CONTINUE READING
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