Tissue-specific estrogenic response and molecular mechanisms.

  title={Tissue-specific estrogenic response and molecular mechanisms.},
  author={Patrick Diel},
  journal={Toxicology letters},
  volume={127 1-3},
Estrogens exert profound effects on growth, differentiation, and function of many reproductive tissues. They also affect other tissues, including bone, liver, cardiovascular system, and brain. In the last few years it has been demonstrated that several synthetic estrogens can act in a tissue-specific manner. The first example of such a selective estrogen receptor modulator (SERM) was tamoxifen, for which an estrogen agonist-like activity in the endometrium and bone was seen to occur… CONTINUE READING