Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance.

@article{Lessard2007TissuespecificEO,
  title={Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance.},
  author={Sarah J. Lessard and Donato A Rivas and Z P Chen and Arend Bonen and Mark Anthony Febbraio and Donald W. Reeder and Bruce E. Kemp and Ben B. Yaspelkis and John A. Hawley},
  journal={Diabetes},
  year={2007},
  volume={56 7},
  pages={1856-64}
}
Both pharmacological intervention (i.e., thiazolidinediones [TZDs]) and lifestyle modification (i.e., exercise training) are clinically effective treatments for improving whole-body insulin sensitivity. However, the mechanism(s) by which these therapies reverse lipid-induced insulin resistance in skeletal muscle is unclear. We determined the effects of 4 weeks of rosiglitazone treatment and exercise training and their combined actions (rosiglitazone treatment and exercise training) on lipid and… CONTINUE READING

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