Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats.

@article{Lynch2002TissuespecificEO,
  title={Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats.},
  author={Christopher J Lynch and Susan M. Hutson and Brian J. Patson and Alain Vaval and Thomas C. Vary},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 4},
  pages={
          E824-35
        }
}
  • C. Lynch, S. Hutson, +2 authors T. Vary
  • Published 1 October 2002
  • Biology
  • American journal of physiology. Endocrinology and metabolism
Acute administration of leucine and norleucine activates the mammalian target of rapamycin (mTOR) cell-signaling pathway and increases rates of protein synthesis in a number of tissues in fasted rats. Although persistent stimulation of mTOR signaling is thought to increase protein synthetic capacity, little information is available concerning the effects of chronic administration of these agonists on protein synthesis, mTOR signal transduction, or leucine metabolism. Hence, we developed a model… 
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TLDR
Leucine activates signaling factor of mammalian target of rapamycin (mTOR) to promote protein synthesis in skeletal muscle and in adipose tissue, and is also a major regulator of the mTOR sensitive response of food intake to high protein diet.
Leucine and alpha-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs.
TLDR
The ability of leucine to act as a nutrient signal to stimulate skeletal muscle protein synthesis is specific forLeucine and/or its metabolite, KIC and neither protein synthesis nor activation of translation initiation factors was affected by treatment.
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TLDR
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Novel findings provide a molecular basis for designing effective nutritional means to increase the efficiency of nutrient utilization for protein accretion in neonates.
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
TLDR
Increases in dietary leucine intake substantially decrease diet-induced obesity, hyperglycemia, and hypercholesterolemia in mice with ad libitum consumption of HFD likely via multiple mechanisms.
Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance.
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