Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury.

@article{Li2009TissuespecificDI,
  title={Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury.},
  author={Li Li and LaWanda H Thompson and Ling Zhao and Joseph Messina},
  journal={Endocrinology},
  year={2009},
  volume={150 1},
  pages={24-32}
}
Acute insulin resistance occurs after injury, hemorrhage, infection, and critical illness. However, little is known about the development of this acute insulin-resistant state. In the current study, we found that insulin resistance develops rapidly in skeletal muscle, with the earliest insulin signaling defects at 60 min. However, defects in insulin signaling were measurable even earlier in liver, by as soon as 15 min after hemorrhage. To begin to understand the mechanisms for the development… CONTINUE READING