Tissue-specific depression of mitochondrial proton leak and substrate oxidation in hibernating arctic ground squirrels.

@article{Barger2003TissuespecificDO,
  title={Tissue-specific depression of mitochondrial proton leak and substrate oxidation in hibernating arctic ground squirrels.},
  author={Jamie L. Barger and Martin D. Brand and Brian M. Barnes and Bert B Boyer},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={284 5},
  pages={R1306-13}
}
A significant proportion of standard metabolic rate is devoted to driving mitochondrial proton leak, and this futile cycle may be a site of metabolic control during hibernation. To determine if the proton leak pathway is decreased during metabolic depression related to hibernation, mitochondria were isolated from liver and skeletal muscle of nonhibernating (active) and hibernating arctic ground squirrels (Spermophilus parryii). At an assay temperature of 37 degrees C, state 3 and state 4… CONTINUE READING