Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation

@article{Sgr2016TissuespecificCO,
  title={Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation},
  author={Francesco Sgr{\`o} and Federico T Bianchi and Mattia Falcone and Gianmarco Pallavicini and Marta Gai and Alessandra A Chiotto and Gaia E Berto and E. Turco and Yoon Jeung Chang and Wieland B Huttner and Ferdinando Di Cunto},
  journal={Cell Death and Differentiation},
  year={2016},
  volume={23},
  pages={801-813}
}
Cytokinesis, the physical separation of daughter cells at the end of cell cycle, is commonly considered a highly stereotyped phenomenon. However, in some specialized cells this process may involve specific molecular events that are still largely unknown. In mammals, loss of Citron-kinase (CIT-K) leads to massive cytokinesis failure and apoptosis only in neuronal progenitors and in male germ cells, resulting in severe microcephaly and testicular hypoplasia, but the reasons for this specificity… CONTINUE READING
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