Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.

@article{Devlin2005TissuespecificCI,
  title={Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.},
  author={Angela M. Devlin and Teodoro G Bottiglieri and F E Domann and Steven R Lentz},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 27},
  pages={25506-11}
}
Expression of the imprinted genes H19 and insulin-like growth factor 2 (Igf2), which lie in close proximity on mouse chromosome 7, is regulated by methylation of a differentially methylated domain (DMD) located 5' to H19. Biallelic expression of H19 has been observed in renal disease patients with hyperhomocysteinemia, a cardiovascular disease risk factor. The present study determined whether hyperhomocysteinemia produces decreased tissue methylation capacity, hypomethylation of the H19 DMD… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…