Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.

  title={Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.},
  author={Angela M. Devlin and Teodoro G Bottiglieri and F E Domann and Steven R Lentz},
  journal={The Journal of biological chemistry},
  volume={280 27},
Expression of the imprinted genes H19 and insulin-like growth factor 2 (Igf2), which lie in close proximity on mouse chromosome 7, is regulated by methylation of a differentially methylated domain (DMD) located 5' to H19. Biallelic expression of H19 has been observed in renal disease patients with hyperhomocysteinemia, a cardiovascular disease risk factor. The present study determined whether hyperhomocysteinemia produces decreased tissue methylation capacity, hypomethylation of the H19 DMD… CONTINUE READING


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