Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model.

@article{Azzam2011TissuespecificAE,
  title={Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model.},
  author={Gregory A Azzam and Amanda K. Frank and M. Hollstein and Maureen E Murphy},
  journal={Cell cycle},
  year={2011},
  volume={10 9},
  pages={1352-5}
}
Currently there are several dozen human polymorphisms that have been loosely associated with cancer risk. Correlating such variants with cancer risk has been challenging, primarily due to factors such as genetic heterogeneity, contributions of diet and environmental factors, and the difficulty in obtaining large sample sizes for analysis. Such difficulties can be circumvented with the establishment of mouse models for human variants. Recently, several groups have modeled human cancer… CONTINUE READING

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