Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice.

@article{Terenzi2007TissuespecificAI,
  title={Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice.},
  author={Fulvia Terenzi and Christine L. White and Srabani Pal and Bryan Raymond George Williams and Ganes C Sen},
  journal={Journal of virology},
  year={2007},
  volume={81 16},
  pages={8656-65}
}
The interferon-stimulated genes (ISGs) ISG56 and ISG54 are strongly induced in cultured cells by type I interferons (IFNs), viruses, and double-stranded RNA (dsRNA), which activate their transcription by various signaling pathways. Here we studied the stimulus-dependent induction of both genes in vivo. dsRNA, which is generated during virus infection, induced the expression of both genes in all organs examined. Induction was not seen in STAT1-deficient mice, indicating that dsRNA-induced gene… CONTINUE READING

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