Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice.

@article{Soares1987TissuespecificAH,
  title={Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice.},
  author={Vera da Costa Soares and R M Gubits and P. Feigelson and Frank D Costantini},
  journal={Molecular and cellular biology},
  year={1987},
  volume={7 10},
  pages={3749-58}
}
To investigate the tissue-specific and hormonal regulation of the rat alpha 2u globulin gene family, we introduced one cloned member of the gene family into the mouse germ line and studied its expression in the resulting transgenic mice. Alpha 2u globulingene 207 was microinjected on a 7-kilobase DNA fragment, and four transgenic lines were analyzed. The transgene was expressed at very high levels, specifically in the liver and the preputial gland of adult male mice. The expression in male… CONTINUE READING