Tissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoter.

@article{Song1998TissuespecificAA,
  title={Tissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoter.},
  author={Chung Seog Song and Myeong Ho Jung and Sun Hee Kim and Tigani Hassan and Arun K. Roy and Bandana Chatterjee},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 34},
  pages={21856-66}
}
Dehydroepiandrosterone sulfotransferase (Std) catalyzes sulfonation of androgenic steroids and certain aromatic procarcinogens. In rats, this enzyme is selectively expressed in the liver, and its expression is strongly repressed by androgens. DNase I footprinting and electrophoretic mobility shift analyses revealed two hepatocyte nuclear factor-1 (HNF1), three CCAAT/enhancer-binding protein (C/EBP), and one consensus palindromic thyroid hormone response elements within the first 215 base pairs… CONTINUE READING