Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

@article{Barker1993TissuespecificAS,
  title={Tissue-specific alternative splicing generates two isoforms of the trkA receptor.},
  author={Phillip A Barker and Catherine Lomen-Hoerth and Erin Gensch and Susan O Meakin and David J Glass and Eric M. Shooter},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 20},
  pages={15150-7}
}
The trkA receptor functions as a signal transducing receptor for nerve growth factor. In this report, we show that alternative splicing results in the production of two distinct trkA isoforms in both rats and humans. These isoforms differ by virtue of a 6-amino acid insertion in their extracellular domain, the placement of which corresponds exactly with the… CONTINUE READING