Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development.

@article{Ulaner2001TissuespecificAS,
  title={Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development.},
  author={Gary A Ulaner and Ji-Fan Hu and Thanh H. Vu and Linda C. Giudice and Andrew R Hoffman},
  journal={International journal of cancer},
  year={2001},
  volume={91 5},
  pages={644-9}
}
Direct genetic manipulations have shown that telomerase-mediated telomere elongation plays a key role in determining cellular replicative capacity and senescence. The mechanisms regulating the production of an active telomerase enzyme are still predominantly unknown, although roles for transcriptional control of hTERT, alternative-splicing of hTERT transcripts, and post-translational phosphorylation of hTERT protein have been advocated. Here we show that hTERT is alternatively spliced in… CONTINUE READING