Tissue-specific alterations in somatostatin mRNA accumulation in streptozocin-induced diabetes.

@article{Papachristou1989TissuespecificAI,
  title={Tissue-specific alterations in somatostatin mRNA accumulation in streptozocin-induced diabetes.},
  author={Dimitrios N Papachristou and Khanh Pham and Hans H. Zingg and Yogesh C. Patel},
  journal={Diabetes},
  year={1989},
  volume={38 6},
  pages={752-7}
}
In streptozocin-induced diabetes in rats, there is a marked increase in the content and release of immunoreactive somatostatin (SLI) from the pancreas and upper gut. To elucidate whether these SLI changes are associated with alterations in somatostatin gene transcription, we measured somatostatin mRNA (SmRNA) accumulation in these and other SLI-producing tissues. Pancreas, stomach, jejunum, hypothalamus, and cerebral cortex were removed from control rats, 6-wk-diabetic rats, and diabetic rats… CONTINUE READING