Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.

@article{Markiewicz1996TissuespecificAO,
  title={Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.},
  author={S Markiewicz and R Bosselut and Françoise le Deist and Jean-Pierre de Villartay and Claire Hivroz and Jacques Ghysdael and Axel Fischer and Genevi{\`e}ve de Saint Basile},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 25},
  pages={14849-55}
}
The gammac chain is a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15), the expression of which is restricted to hematopoietic lineages. A defect in gammac leads to the X-linked severe combined immunodeficiency characterized by a block in T cell differentiation. In order to better characterize the human gammac promoter and define the minimal tissue-specific promoter region, progressive 5'-deletion constructs of a segment extending 1053 base pairs upstream… CONTINUE READING