Tissue-specific Induction Patterns of Cancer-protective Enzymes in Mice by tert-Butyl-4-hydroxyanisole and Related Substituted Phenols1

Abstract

Some of the anticarcinogenic effects of 2(3)-ferf-butyl-4-hydroxyanisole (BHA) are attributable to the induction of detoxifying enzymes in the liver and peripheral tissues. This study was designed to determine if the tissue specificity of enzyme induc tion could be manipulated by structural modification of BHA. The induction of glutathione S-transferases… (More)

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