Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.

  title={Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.},
  author={F{\'e}rd{\'e}ric Charron and Georgios Tsimiklis and Marcel Arcand and Lynda Robitaille and Qiming Liang and Jeffery D Molkentin and Sylvain Meloche and Mona Nemer},
  journal={Genes & development},
  volume={15 20},
Rho-like GTPases play a pivotal role in the orchestration of changes in the actin cytoskeleton in response to receptor stimulation, and have been implicated in transcriptional activation, cell growth regulation, and oncogenic transformation. Recently, a role for RhoA in the regulation of cardiac contractility and hypertrophic cardiomyocyte growth has been suggested but the mechanisms underlying RhoA function in the heart remain undefined. We now report that transcription factor GATA-4, a key… CONTINUE READING


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