Tissue responses to molecularly reinforced polylactide-co-glycolide implants.

  title={Tissue responses to molecularly reinforced polylactide-co-glycolide implants.},
  author={Kai Uwe Lewandrowski and Jessica Gresser and Donald L. Wise and Debra J. Trantolo and Vasif Hasirci},
  journal={Journal of biomaterials science. Polymer edition},
  volume={11 4},
Plates for internal fixation fabricated from biodegradable polymers degrade via an autocatalytic route. When they are used in bone implants of significant size and thickness, hollowing of the implant may occur while the overall dimensions appear unchanged. We hypothesized that incorporation of a cross-linked polypropylene fumarate matrix into polylactide-co-glycolide bone plates may provide an internal molecular network which prevents implant collapse. Cross-linking reagents of varying… CONTINUE READING