Tissue response to intramuscular and intraperitoneal injections of ketamine and xylazine in rats.

@article{Smiler1990TissueRT,
  title={Tissue response to intramuscular and intraperitoneal injections of ketamine and xylazine in rats.},
  author={K L Smiler and Sherman Stein and K L Hrapkiewicz and J R Hiben},
  journal={Laboratory animal science},
  year={1990},
  volume={40 1},
  pages={60-4}
}
Ketamine-xylazine is a widely accepted anesthetic combination for laboratory animals. Although frequently recommended for administration by intramuscular (IM) or intraperitoneal (IP) routes, the potential for tissue damage following either route of administration in the rat has not been investigated. This study evaluated tissue damage after IM use at two doses in Fischer 344 and Sprague-Dawley rats. Tissue reactions following IP injections of ketamine-xylazine were compared to lesions produced… CONTINUE READING