Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion.

@article{Pinilla2009TissueRS,
  title={Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion.},
  author={Severin P Pinilla and Eckhard U. Alt and Feras J Abdul Khalek and Constantin Jotzu and Fabian Muehlberg and Christoph Beckmann and Y Song},
  journal={Cancer letters},
  year={2009},
  volume={284 1},
  pages={80-5}
}
In the present study, we investigated whether human adipose tissue derived stem cells (hASCs) could enhance tumor invasion and whether these hASCs could be a potential source of CCL5. We observed a significant increase in the number of breast cancer cells that invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in the Co-culture and cancer cell invasion was diminished by an antibody against CCL5. Furthermore, cancer cell invasion in the Co-culture was associated… CONTINUE READING

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