Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection.

@article{Bunn2014TissueRF,
  title={Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection.},
  author={Patrick T. Bunn and Amanda C. Stanley and Fabian de Labastida Rivera and Alexander Mulherin and Meru Sheel and Clare E Alexander and Rebecca J. Faleiro and Fiona H Amante and Marcela Montes de Oca and Shannon E. Best and Kylie R James and Paul M. Kaye and Ashraful Haque and Christian R Engwerda},
  journal={Journal of immunology},
  year={2014},
  volume={192 8},
  pages={3709-18}
}
Organ-specific immunity is a feature of many infectious diseases, including visceral leishmaniasis caused by Leishmania donovani. Experimental visceral leishmaniasis in genetically susceptible mice is characterized by an acute, resolving infection in the liver and chronic infection in the spleen. CD4+ T cell responses are critical for the establishment and maintenance of hepatic immunity in this disease model, but their role in chronically infected spleens remains unclear. In this study, we… CONTINUE READING

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