Tissue repair and stem cell renewal in carcinogenesis

  title={Tissue repair and stem cell renewal in carcinogenesis},
  author={Philip A Beachy and Sunil S. Karhadkar and David M. Berman},
Cancer is increasingly being viewed as a stem cell disease, both in its propagation by a minority of cells with stem-cell-like properties and in its possible derivation from normal tissue stem cells. But stem cell activity is tightly controlled, raising the question of how normal regulation might be subverted in carcinogenesis. The long-known association between cancer and chronic tissue injury, and the more recently appreciated roles of Hedgehog and Wnt signalling pathways in tissue… CONTINUE READING
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