Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation.

@article{Mangia2011TissueRI,
  title={Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation.},
  author={Anita Mangia and Andrea Malfettone and Roberta Simona Rossi and Angelo Virgilio Paradiso and Girolamo Ranieri and Giovanni Simone and Leonardo Resta},
  journal={Histopathology},
  year={2011},
  volume={58 7},
  pages={1096-106}
}
AIMS Cancerogenesis is characterized by increase of differentiated myofibroblasts. Mast cells (MCs) exert powerful effects on fibroblasts through a variety of mediators. We investigated α-smooth-muscle actin (α-SMA(+) ) and CD34(+) fibroblasts, density of toluidine blue-stained (MCs-TB) and tryptase-immunolabelled MCs (MCs-Try) in 30 primary breast tumours. METHODS AND RESULTS Tumour (T), peri-tumoral (PT) and non-tumoral (NT) tissue was studied by immunohistochemistry and electron microscopy… CONTINUE READING