Tissue reconstruction in 3D-spheroids from rodent retina in a motion-free, bioreactor-based microstructure.

@article{Rieke2008TissueRI,
  title={Tissue reconstruction in 3D-spheroids from rodent retina in a motion-free, bioreactor-based microstructure.},
  author={Matthias Rieke and Eric Gottwald and Karl-Friedrich Weibezahn and Paul Gottlob Layer},
  journal={Lab on a chip},
  year={2008},
  volume={8 12},
  pages={2206-13}
}
While conventional rotation culture-based retinal spheroids are most useful to study basic processes of retinogenesis and tissue regeneration, they are less appropriate for an easy and inexpensive mass production of histotypic 3-dimensional tissue spheroids, which will be of utmost importance for future bioengineering, e.g. for replacement of animal experimentation. Here we compared conventionally reaggregated spheroids derived from dissociated retinal cells from neonatal gerbils (Meriones… CONTINUE READING