Tissue reaction to ceramic implant material.

  title={Tissue reaction to ceramic implant material.},
  author={J{\"u}rgen Harms and E. M{\"a}usle},
  journal={Journal of biomedical materials research},
  volume={13 1},
The biocompatibility of alumina ceramic was tested by means of macrophage cultures, intraperitoneal (i.p.) and intramuscular (i.m.) application of powdered particles in rats, and by implantation of solid samples in the paravertebral muscles and the condylus femur. No acute cytotoxicity was found in macrophage cultures. The i.p. and i.m. application of powdered particles in the beginning showed a granulocytic reaction, later followed by a histiocytic reaction. Also, the morphological changes in… CONTINUE READING


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