Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.

@article{Jacobs2012TissuePA,
  title={Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.},
  author={Elizabeth R. Jacobs and Sreedhar Bodiga and Irshad Ali and Aaron M Falck and J Russel Falck and Meetha M Medhora and Anuradha Dhanasekaran},
  journal={Experimental cell research},
  year={2012},
  volume={318 16},
  pages={2143-52}
}
The capacity to follow cell type-specific signaling in intact lung remains limited. 20-hydroxyeicosatetraenoic acid (20-HETE) is an endogenous fatty acid that mediates signaling for a number of key physiologic endpoints in the pulmonary vasculature, including cell survival and altered vascular tone. We used confocal microscopy to identify enhanced reactive oxygen species (ROS) production in endothelial cell (EC)s in intact lung evoked by two stable analogs of 20-HETE, 20-5,14-HEDE (20… CONTINUE READING