Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac

@article{Nugent1996TissuePL,
  title={Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac},
  author={Karen Nugent and Allan D Spigelman and Robin K. S. Phillips},
  journal={Diseases of the Colon \& Rectum},
  year={1996},
  volume={39},
  pages={659-662}
}
BACKGROUND: Recent work has demonstrated a correlation between frequency of aspirin ingestion and colorectal cancer prevention. Sulindac, another nonsteroidal anti-inflammatory drug (NSAID), has been shown to cause polyp regression and a fall in cell proliferation in patients with familial adenomatous polyposis, who are destined to develop colorectal cancer unless the colon is removed. However, the mode of action of NSAIDs in colorectal carcinogenesis prevention remains to be determined… Expand
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