Tissue preconditioning may explain concentric lesions in Baló's type of multiple sclerosis.

@article{Stadelmann2005TissuePM,
  title={Tissue preconditioning may explain concentric lesions in Bal{\'o}'s type of multiple sclerosis.},
  author={Christine Stadelmann and Samuel K. Ludwin and Takeshi Tabira and Andr{\'a}s Guseo and Claudia F. Lucchinetti and L{\'o}r{\'a}nt Leel-{\^O}ssy and Artemio T. Ordinario and Wolfgang Br{\"u}ck and Hans Lassmann},
  journal={Brain : a journal of neurology},
  year={2005},
  volume={128 Pt 5},
  pages={
          979-87
        }
}
Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated and demyelinated tissue. The reason for concentric demyelination in this variant of multiple sclerosis is unclear. In the present study we investigated the immunopathology in autopsy tissue of 14 patients with acute multiple sclerosis or fulminant exacerbations of chronic multiple sclerosis with Baló-type lesions in the CNS, focusing on the patterns of tissue injury in actively demyelinating lesions. We… 

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