Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels

Abstract

BACKGROUND The frizzled (fz) gene of Drosophila encodes the founding member of the large family of receptors for the Wnt family of signaling molecules. It was originally studied in the adult epidermis, where it plays a key role in the generation of tissue polarity. Mutations in components of the fz signal transduction pathway disrupt tissue polarity; on the… (More)
DOI: 10.1016/S0960-9822(06)00413-1

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