Tissue plasminogen activator thrombolytic therapy for acute ischemic stroke in 4 hospital groups in Japan.

@article{Kono2013TissuePA,
  title={Tissue plasminogen activator thrombolytic therapy for acute ischemic stroke in 4 hospital groups in Japan.},
  author={Syoichiro Kono and Kentaro Deguchi and Nobutoshi Morimoto and Tomoko Kurata and Shoko Deguchi and Tohru Yamashita and Yoshio Ikeda and Tohru Matsuura and Hisashi Narai and Nobuhiko Omori and Yasuhiro Manabe and Taijyun Yunoki and Yoshiki Takao and Sanami Kawata and Kenichi Kashihara and Koji Abe},
  journal={Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year={2013},
  volume={22 3},
  pages={190-6}
}
In October 2005 in Japan, the recombinant tissue plasminogen activator (tPA) alteplase was approved for patients with acute ischemic stroke within 3 hours of onset at a dose of 0.6 mg/kg. The present study was undertaken to assess the safety and efficacy of alteplase in Japan. Between October 2005 and December 2009, a total of 114 consecutive patients admitted to 4 hospitals received intravenous tPA within 3 hours of stroke onset. Clinical backgrounds and outcomes were investigated. The… CONTINUE READING
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