Tissue plasminogen activator promotes platelet disaggregation in plasma.

  title={Tissue plasminogen activator promotes platelet disaggregation in plasma.},
  author={Joseph Loscalzo and Douglas E. Vaughan},
  journal={The Journal of clinical investigation},
  volume={79 6},
We studied the disaggregation of human platelets by tissue-type plasminogen activator (t-PA). When added to a suspension of human platelets induced to aggregate in plasma with adenosine 5'-diphosphate, t-PA promoted disaggregation of platelets over several minutes. Addition of fresh plasma or purified human fibrinogen to disaggregated platelets facilitated (reversible) aggregation and subsequent disaggregation. Aspirin treatment of platelets markedly potentiated the ability of t-PA to induce… CONTINUE READING


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